Chimeric plasmid containing secretable exendin-4 expression cassette was constructed based on TSTA system used in a previously experiment [ 2123 ]. Drugs This result means that PAM-ABP polymer and plasmids coding exendin-4 did not induce polyplex-associated hepatic injury. MahatoSung Wan Kim Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics presents a comprehensive account of gene therapy, from development in the laboratory, to clinical applications, with an emphasis on cardiovascular and autoimmune diseases as well as cancer. Association AD Diagnosis and classification of diabetes mellitus.
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A BPRB, 20 South East Salt Lake City, UT PHONE: FAX: Email address: @ Dr. Kim is a pioneer in drug delivery research and has engaged in his research since in the areas of hydrogels, biodegradable drug conjugates. Sung Wan Kim of Kyung Hee University, Seoul | Read publications | Contact Sung Wan Kim.
University of Utah. Sokwon Kim. University of Ulsan. Cited By.
In this study, we newly constructed chimeric plasmid expression vector encoding secretable exendin-4 into one plasmid to improve efficiency and efficacy of TSTA system using two plasmids as polymeric-plasmid based gene therapy.
Diabetes Care Halaman: Size distribution and zeta-potential values were determined as the change in polyplex according to the increase of PAM-ABP polymer ratios from to Besides, exendin-4 plays a roles as an increase in glucose transport in muscle and glucose transporter expression and glycogen synthesis in liver [ 89 ], as well as the improvement of heart function against myocardial infarction [ 10 ] and the enhancement of central nervous system in brain [ 11 ].
In this study, we investigated an effective anti-diabetic therapy via exendin-4 expressing chimeric plasmid based on two-step transcription amplification TSTA system with dendrimer-type bioreducible polymer for more improved incretin based gene therapy.
He is the Founder and Co-Director of the University of Utah's Center for. included in Diversity and Inclusion Email To learn more: edu/pharmaceutics/ Two Elected National Academy Members: Sung Wan Kim, National Academy of Medicine and National Email Address. 29 more addresses found for Sung Won Kim Hales Corners WI: S Sunny River Rd Salt Lake Cty UT August - July We currently show as many as 29 address, 5 phones, 1 email addresses for Sung Kim.
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Regul Pept Diabetes Chimeric TSTA plasmid condensation via PAMABP dendritic cationic polymer delineate therapeutic potential of polymeric based gene therapy using efficient gene expression system and superior gene delivery carrier, enabling improve anti-diabetic effects. MahatoSung Wan Kim Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics presents a comprehensive account of gene therapy, from development in the laboratory, to clinical applications, with an emphasis on cardiovascular and autoimmune diseases as well as cancer.
Verspohl EJ Novel therapeutics for type 2 diabetes: incretin hormone mimetics glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Biomaterials
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Chimeric TSTA plasmid condensation via PAMABP dendritic cationic polymer delineate therapeutic potential of polymeric based gene therapy using efficient gene expression system and superior gene delivery carrier, enabling improve anti-diabetic effects.
Ahren B The future of incretin-based therapy: novel avenues--novel targets. Mol Ther In that point of view, our systems based on polymeric gene therapy showed long-lasting effects to lower high blood glucose via once intravenous injection.
Sung Kim found in Utah (UT) with results in 12 cities. home address, phone numbers, social media profiles, emails and dark web Sung Won Kim.
Abstract The gel to sol transition of aqueous solutions of di‐ and triblock copolymers consisting of poly(ethylene oxide) and biodegradable.
The low cytotoxicity of bioreducible polymer including ABP and PAM-ABP compared with 25 K PEI causes that the disulfide bonds in their structure is degraded into non-toxic small molecules in reductive environment such as cytoplasm in cells Supplementary Figure 2 [ 222428 ].
This result means that PAM-ABP polymer and plasmids coding exendin-4 did not induce polyplex-associated hepatic injury.
Sung Wan Kim University of Utah
Furthermore, incretin effects by exendin-4 were dependent on exendin-4 expression. ISRN Endocrinol Diabetes Care 1: SS Technically, to induce optimum expression of transgene in TSTA system itself, two plasmids should be delivered into a same cell.
In current clinical field, two kinds of exendinassociated therapeutic agents including recently FDA approval agent have used [ 3 ].
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|Current trends in diabetes treatment using incretin hormones field include strategies to induce long-term therapeutic period and to increase efficacy.
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This is enough size capable of passing into liver. Free fatty acid FFA has been implicated to play an important role in insulin resistance in obese patients with type 2 diabetes. Also, insulin resistance is a representative trademark of type 2 diabetes and it often precedes the onset of hyperglycemia and indicates the elevations of lipid level in body. Eur J Pharm Sci The construction of the plasmids was confirmed by restriction enzyme studies and direct sequencing.