Eighteen days after initiation of chemotherapy, the patient developed dyspnea. Lower extremity ultrasonography imaging showing diffuse muscle edema with a thin fluid layer along the intermuscularfascial plane, which suggests myositis. CT features may not be specific and the clinical context is extremely useful in image interpretation. Subject alert. Systems: ChestHaematology.
(RAS) is a potentially life-threatening complication observed in people with acute promyelocytic leukemia (APML) and first thought to be specifically associated with all.
Retinoic acid syndrome (RAS) is a potentially life-threatening complication observed in people with acute promyelocytic leukemia (APML) and first thought to be specifically associated with all-trans retinoic acid (ATRA) (also. The retinoic acid syndrome (RAS) is an unpredictable but frequent complication which may develop after administration of all-trans retinoic acid (ATRA) most.
Use of all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. This has led to the growing deprecation of the term 'retinoic acid syndrome' and to an increasing use of the term differentiation syndrome to signify this APML treatment complication.
Although diagnosis of microgranular-variant APL has not been considered prognostically significant, a recent study 4 showed that it results in higher death rates within 30 days of induction therapy. Image 1. Oxford University Press is a department of the University of Oxford. Creatine kinase CK levels were elevated, and magnetic resonance imaging MRI and leg-muscle biopsy results were also in accordance with myositis Images 2A3Aand 3B.
Incidence, clinical features, and outcome of all trans-retinoic acid syndrome in cases of newly diagnosed acute promyelocytic leukemia. The treatment of acute promyelocytic leukemia with all-trans-retinoic acid (ATRA) sometimes results in a syndrome characterized by fever, respiratory distress.
Video: Trans retinoic acid syndrome Acute Promyelocytic Leukema (aPML) - t(15;17) - AML_M3 - ATRA
The cause of RAS is not clear. Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys.
An elevated white count is sometimes associated with this syndrome, but is not always pathognomonic. Mediation by cathepsin G has been suggested. Download all figures.
Alltrans retinoic acid syndrome Radiology Reference Article
The retinoic acid syndrome (RAS) is an unpre- dictable but frequent complication which may develop after administration of all-trans retinoic acid (ATRA) most.
Patient Cases. Unable to process the form. About Blog Go ad-free. Will depend on the system involved although many of the features are described in relation to the lungs. All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.
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